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UniversidaddeCádiz
CTS554 Metabolismo del Fosfato y Neuroimagen Experimental


Información ORCID de RUIZ RODRIGUEZ, FELIX ALEJANDRO


Biografía


Professor at University of Cadiz, Spain. Researcher​ in Biomedicine.\nOn the summer of 2004, I moved to Cadiz (Spain) in order to star and direct a new research group: Human Phosphate Research Group (Hupho Group), interested in the study of phosphate polymers in human cells and tissues.


Educación


Doctor in Philosophy (Ph.D.) (Bioquímica y Biología Molecular)

Universidad Autónoma de Madrid: Madrid, Madrid, España

1996 hasta 1999


Bachelor's degree (\ (Biology, Science)

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

1988 hasta 1994



Empleo


Tenured professor - \ (Biomedicina, Biotecnología y Salud Pública)

Universidad de Cádiz: Cadiz, Andalucía, España

12/2010


Tenured - \ (Biomedicina, Biotecnología y Salud Pública)

Universidad de Cádiz: Cadiz, Andalucía, España

08/2009 hasta 12/2010


Tenure-track research professorship (\ (Bioquímica, Biología Molecular... )

Universidad de Cádiz: Cadiz, Andalucía, España

07/2004 hasta 08/2009


Postdoctoral Research Associate (Veterinary Pathobiology (College of Veterinary Medicine))

University of Illinois at Urbana-Champaign: Urbana, IL, US

01/2000 hasta 06/2004


Postdoctoral fellow (Medicine. Division of Hepatology and Gene Therapy)

Universidad de Navarra Facultad de Medicina: Pamplona, Navarra, España

1999 hasta 1999


Predoctoral fellow

Instituto de Investigaciones Biomédicas Alberto Sols: Madrid, Madrid, España

1996 hasta 1998



Obras


Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body Pathway

2021 | JOURNAL_ARTICLE

DOI: 10.3390/cells10113161

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Targeting Protein Kinase C in Glioblastoma Treatment

2021 | JOURNAL_ARTICLE

DOI: 10.3390/biomedicines9040381

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Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action

2020 | JOURNAL_ARTICLE

DOI: 10.1038/s41386-020-00934-y

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A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries.

2020 | JOURNAL_ARTICLE

DOI: 10.1038/s41419-020-2453-9

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Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome.

2018 | JOURNAL_ARTICLE

DOI: 10.1021/acschembio.8b00357

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Novel assay for prothrombotic polyphosphates in plasma reveals their correlation with obesity

2016 | JOURNAL_ARTICLE

DOI: 10.1016/j.thromres.2016.06.003

EID: 2-s2.0-84973508210

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Biomarkers of the prothrombotic state in abdominal obesity

2015 | JOURNAL_ARTICLE

DOI: 10.3305/nh.2015.31.3.8168

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NOA36 Protein Contains a Highly Conserved Nucleolar Localization Signal Capable of Directing Functional Proteins to the Nucleolus, in Mammalian Cells

2013 | JOURNAL_ARTICLE

DOI: 10.1371/journal.pone.0059065

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Myeloma cells contain high levels of inorganic polyphosphate which is associated with nucleolar transcription

2012 | JOURNAL_ARTICLE

DOI: 10.3324/haematol.2011.051409

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Polyphosphate binds to human von Willebrand factor in vivo and modulates its interaction with glycoprotein Ib

2012 | JOURNAL_ARTICLE

DOI: 10.1111/jth.12004

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Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes

2012 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M112.385823

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High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease

2009 | JOURNAL_ARTICLE

DOI: 10.1111/j.1742-4658.2009.07183.x

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Platelet inorganic polyphosphate decreases in patients with delta storage pool disease

2009 | JOURNAL_ARTICLE

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Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression

2008 | JOURNAL_ARTICLE

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Organellar proteomics of human platelet dense granules reveals that 14-3-3 zeta is a granule protein related to atherosclerosis

2007 | JOURNAL_ARTICLE

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Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation

2007 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M704841200

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Inorganic polyphosphate and specific induction of apoptosis in human plasma cells

2006 | JOURNAL_ARTICLE

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The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence

2005 | JOURNAL_ARTICLE

DOI: 10.1111/j.1365-2958.2004.04464.x

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A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice

2004 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M309974200

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Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii

2004 | JOURNAL_ARTICLE

DOI: 10.1242/jcs.01495

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Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes

2004 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M406261200

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Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation

2004 | JOURNAL_ARTICLE

DOI: 10.1083/jcb.200309097

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Polyphosphate content and fine structure of acidocalcisomes of Plasmodium faiciparum

2004 | JOURNAL_ARTICLE

DOI: 10.1017/S1431927604040875

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Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes

2003 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M304548200

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A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei

2002 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M204744200

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Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum

2002 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M111130200

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An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short chain polyphosphate

2002 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M208940200

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Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate

2002 | JOURNAL_ARTICLE

DOI: 10.1074/jbc.M208990200

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Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats

2002 | JOURNAL_ARTICLE

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Regulation of mammalian liver methionine adenosyltransferase

2002 | JOURNAL_ARTICLE

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Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi

2001 | JOURNAL_ARTICLE

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TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi

2001 | JOURNAL_ARTICLE

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The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and axe similar to acidocalcisomes

2001 | JOURNAL_ARTICLE

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Creation of a functional S-nitrosylation site in vitro by single point mutation

1999 | JOURNAL_ARTICLE

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In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver

1999 | JOURNAL_ARTICLE

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Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol

1999 | JOURNAL_ARTICLE

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Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation

1998 | JOURNAL_ARTICLE

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Specific interaction of methionine adenosyltransferase with free radicals

1998 | JOURNAL_ARTICLE

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Interaction of liver methionine adenosyltransferase with hydroxyl radical

1997 | JOURNAL_ARTICLE

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CHARACTERIZATION OF THE PLASMA-MEMBRANE CALCIUM-PUMP FROM TRYPANOSOMA-CRUZI

1995 | JOURNAL_ARTICLE

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