ORCID

Información ORCID de RUIZ RODRIGUEZ, FELIX ALEJANDRO

Biografía

Professor at University of Cadiz, Spain. Researcher in Biomedicine.\nOn the summer of 2004, I moved to Cadiz (Spain) in order to star and direct a new research group: Human Phosphate Research Group (Hupho Group), interested in the study of phosphate polymers in human cells and tissues.

Educación

Doctor in Philosophy (Ph.D.) (Bioquímica y Biología Molecular)

Universidad Autónoma de Madrid: Madrid, Madrid, España

1996 hasta 1999

Bachelor's degree (\ (Biology, Science)

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

1988 hasta 1994

Empleo

Tenured professor - \ (Biomedicina, Biotecnología y Salud Pública)

Universidad de Cádiz: Cadiz, Andalucía, España

12/2010

Tenured - \ (Biomedicina, Biotecnología y Salud Pública)

Universidad de Cádiz: Cadiz, Andalucía, España

08/2009 hasta 12/2010

Tenure-track research professorship (\ (Bioquímica, Biología Molecular... )

Universidad de Cádiz: Cadiz, Andalucía, España

07/2004 hasta 08/2009

Postdoctoral Research Associate (Veterinary Pathobiology (College of Veterinary Medicine))

University of Illinois at Urbana-Champaign: Urbana, IL, US

01/2000 hasta 06/2004

Postdoctoral fellow (Medicine. Division of Hepatology and Gene Therapy)

Universidad de Navarra Facultad de Medicina: Pamplona, Navarra, España

1999 hasta 1999

Predoctoral fellow

Instituto de Investigaciones Biomédicas Alberto Sols: Madrid, Madrid, España

1996 hasta 1998

Obras

Polyphosphate Activates von Willebrand Factor Interaction with Glycoprotein Ib in the Absence of Factor VIII In Vitro

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Información ORCID de RUIZ RODRIGUEZ, FELIX ALEJANDRO

Biografía

Educación

Doctor in Philosophy (Ph.D.) (Bioquímica y Biología Molecular)

Bachelor's degree (\ (Biology, Science)

Empleo

Tenured professor - \ (Biomedicina, Biotecnología y Salud Pública)

Tenured - \ (Biomedicina, Biotecnología y Salud Pública)

Tenure-track research professorship (\ (Bioquímica, Biología Molecular... )

Postdoctoral Research Associate (Veterinary Pathobiology (College of Veterinary Medicine))

Postdoctoral fellow (Medicine. Division of Hepatology and Gene Therapy)

Predoctoral fellow

Obras

Polyphosphate Activates von Willebrand Factor Interaction with Glycoprotein Ib in the Absence of Factor VIII In Vitro

Proinflammatory Polyphosphate Increases in Plasma of Obese Children with Insulin Resistance and Adults with Severe Type 2 Diabetes

Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body Pathway

Targeting Protein Kinase C in Glioblastoma Treatment

Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries.

Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome.

Novel assay for prothrombotic polyphosphates in plasma reveals their correlation with obesity

Biomarkers of the prothrombotic state in abdominal obesity

NOA36 Protein Contains a Highly Conserved Nucleolar Localization Signal Capable of Directing Functional Proteins to the Nucleolus, in Mammalian Cells

Myeloma cells contain high levels of inorganic polyphosphate which is associated with nucleolar transcription

Polyphosphate binds to human von Willebrand factor in vivo and modulates its interaction with glycoprotein Ib

Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes

High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease

Platelet inorganic polyphosphate decreases in patients with delta storage pool disease

Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression

Organellar proteomics of human platelet dense granules reveals that 14-3-3 zeta is a granule protein related to atherosclerosis

Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation

Inorganic polyphosphate and specific induction of apoptosis in human plasma cells

The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence

A pyrophosphatase regulating polyphosphate metabolism in acidocalcisomes is essential for Trypanosoma brucei virulence in mice

Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii

Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes

Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation

Polyphosphate content and fine structure of acidocalcisomes of Plasmodium faiciparum

Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes

A vacuolar-type H+-pyrophosphatase governs maintenance of functional acidocalcisomes and growth of the insect and mammalian forms of Trypanosoma brucei

Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum

An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short chain polyphosphate

Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate

Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats

Regulation of mammalian liver methionine adenosyltransferase

Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation, and environmental stress in Trypanosoma cruzi

TcSCA complements yeast mutants defective in Ca2+ pumps and encodes a Ca2+-ATPase that localizes to the endoplasmic reticulum of Trypanosoma cruzi

The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and axe similar to acidocalcisomes

In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver.

Creation of a functional S-nitrosylation site in vitro by single point mutation.

Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol.

Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation.

Specific interaction of methionine adenosyltransferase with free radicals.

Interaction of liver methionine adenosyltransferase with hydroxyl radical.

Characterization of the plasma-membrane calcium pump from Trypanosoma cruzi.